Reference Range
Hb A
0-30 days: 10-40%
1-14 months: Adult by 6 mo.
> or = 15 months: 95-98%
Hb A2
0-30 days: <1%
1-11 months: Adult by 12 mo.
> or = 1 year: 2.0-3.3%
Hb F
0-30 days: 60-90%
1-23 months: Adult by 24 mo.
> or = 24 months: 0-2%
No abnormal variants
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Nat Ctr Biotech Info (search for hemoglobin) |
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AlphaThalBrochure alphat1.pdf |
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No abnormal hemoglobins detected. Normal adult hemoglobin electrophoresis.
No abnormal hemoglobins detected. Normal adult hemoglobin electrophoresis.*NOTE: Microcytosis with a normal RDW and hemoglobin electrophoresis can be seen with alpha-thalassemia trait. However, this is a diagnosis of exclusion, and should be considered only when other causes of microcytosis have been investigated and excluded. Alpha thalassemia trait is a clinically benign disorder but offspring of the patient who coinherit alpha thalassemia gene(s) from the other parent may develop medically significant thalassemia.
Hemoglobin electrophoresis shows no abnormal hemoglobins. MCV is low with elevated RDW suggesting iron deficiency. Recommend iron studies if medically indicated. The possibility of alpha or beta thalassemia trait masked by iron deficiency cannot be excluded.
Hemoglobin electrophoresis shows elevated hemoglobin A2 with reduced MCV. These findings are consistent with beta thalassemia trait but other causes of microcytosis such as iron deficiency should be ruled out. Beta thalassemia trait is a clinically benign disorder but offspring may coinherit a beta thalassemia gene from the other parent making them homozygous which may give medically significant thalassemia.
Hemoglobin A2 is elevated suggestive of beta thalassemia trait but complete analysis is not possible without a CBC for red cell indices. No other hemoglobin abnormalities detected. Beta thalassemia trait is a clinically benign disorder but offspring may coinherit a beta thalassemia gene from the other parent making them homozygous which may give medically significant thalassemia.
Hemoglobin electrophoresis shows slightly elevated hgb A2 which may be a variant of normal. No other abnormal hemoglobins detected.
Elevated hemoglobin A2 may be seen in hyperthyroidism.
Microcytosis with a normal RDW and hemoglobin electrophoresis can be seen with alpha-thalassemia trait, a clinically benign disorder. However, this is a diagnosis of exclusion, and should be considered only when other causes of microcytosis have been investigated and excluded.
Hemoglobin electrophoresis consistent with sickle cell trait, unless patient has been recently transfused. Slightly elevated levels of Hgb A2 can be seen in association with sickle cell trait.
Hemoglobin electrophoresis is consistent with sickle cell disease.
SICKLE CELL DISEASE, S/P TRANSFUSION
Hemoglobin electrophoresis is consistent with sickle cell disease status-post transfusion.
SICKLE CELL TRAIT/ ALPHA THAL TRAIT
Hemoglobin electrophoresis is consistent with sickle cell trait unless the patient has been transfused. The patient's hgb S level is lower than that typically seen in sickle cell trait and the MCV is reduced. These findings are consistent with sickle cell trait with concomitant alpha thalassemia trait. Other causes of microcytosis should be ruled out.
Hemoglobin electrophoresis is consistent with hgb S/C disease. Hemoglobin C represents __% of total hemoglobin. Hemoglobin S/C disease is generally associated with mild hemolytic anemia and occasional infarctive crises with splenomegally. These patients are at increased risk for ocular complications, renal medulary infarcts, and avascular necrosis of the femoral head.
Hemoglobin electrophoresis is consistent with hemoglobin C trait unless patient has been recently transfused. Hemoglobin C represents ____% of total hemoglobin. Hemoglobin C trait is a clinically benign condition but may be clinically significant in offspring who are homozygous or coinherit hemoglobin S.
Hemoglobin electrophoresis shows slightly elevated hgb F for age. This may be a variant of normal. It may also be associated with a variety of clinical conditions. Recommend clinical correlation. No other abnormal hemoglobins detected.
Hemoglobin electrophoresis shows elevated hemoglobin F. This may be due to hereditary persistence of fetal hemoglobin, a clinically benign condition, or to other clinical conditions. No other abnormal hemoglobins detected. Recommend clinical correlation.
Hemoglobin electrophoresis is consistent with hemoglobin E trait unless patient has been transfused. Hemoglobin E represents __% of total hemoglobin. Hemoglobin E heterozygotes are assymptomatic with normal hemoglobin level but with microcytosis. Offspring who coinherit hemoglobin E and beta thalassemia may have a more severe anemia than would be the case with either alone.
Complete analysis is not possible without a CBC for red cell indices.
RECOMMEND REPEAT STUDY FOR ELEVATED F
Recommend repeat study at approximately one year of age when physiologic hemoglobin F has cleared if medically indicated.
Hemoglobin electrophoresis shows predominantly hemoglobin A. There is also a hemoglobin variant that constitutes __% of the total hemoglobin. Our findings are consistent with this being a hemoglobin D or G variant indicating that the patient has hgb D or G trait. Hemoglobin D and G traits are clinically benign but may be clinically significant in offspring who are homozygous for the variant or coinherit it with a different variant such as hemoglobin S. Additional studies should be ordered if it is necessary to definitively identify this hemoglobin variant. The specimen will be retained in the laboratory for 7 days.
Hemoglobin electrophoresis shows approximately equal amounts of hemoglobin Aand a variant hemoglobin that is represents __% of the total hemoglobin.This variant appears to be either a J or N variant and is in all likelihood N Baltimore. Most J and N hemoglobins are clinically benign and N Baltimore causes no hematologic abnormalities. This patient's red cells showed no microcytosis which indicates that the variant is very unlikely to be medically significant. The laboratory should be contacted if a definitive diagnosis is necessary in which case the sample will be sent to a reference laboratory. The sample will be held in the lab for 7 days.
