Urine Immunofixation Interpretations MAIN

 


Normal or Proteinuria

Normal immunofixation of urine. No monoclonal immunoglobulin is detected.

Immunofixation of concentrated urine demonstrates polyclonal immunoglobulins. No monoclonal paraprotein is detected.

Immunofixation of urine demonstrates large amounts of polyclonal immunoglobulins with both kappa and lambda light chains, but no paraprotein.

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Inflammation

 

Immunofixation of concentrated urine demonstrates many bands in the kappa lane. This is a nonspecific pattern usually associated with inflammation. No monoclonal paraprotein is detected.

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LADDER PATTERN

Immunofixation of concentrated urine demonstrates many bands in the kappa lane. This is a nonspecific pattern usually associated with inflammation. No monoclonal paraprotein is detected.

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Band not paraprotein

Immunofixation of urine shows no paraprotein. The suspect band in the alpha 2 region does not detectably stain with any of the immunoglobulin reagents.

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Paraprotein

Immunofixation of urine demonstrates a dense band of free kappa light chains and a trace amount of IgI kappa paraprotein.

Immunofixation of urine demonstrates a dense band of free kappa light chains (Bence Jones protein).

Immunofixation of urine demonstrates a monoclonal IgG lambda paraprotein corresponding to the abnormal protein detected on electrophoresis.

Immunofixation of urine demonstrates a major monoclonal free kappa light chain paraprotein band. In addition, there is a monoclonal IgG lambda paraprotein present in lower concentration. This patient has a biclonal gammopathy as defined by an IgG lambda and an IgM kappa paraprotein in the serum. The free kappa paraprotein is not detected in the serum because of efficient urinary excretion of free light chains.

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Bence Jones Protein

Immunofixation of urine demonstrates a dense band of free kappa light chains corresponding to the band seen on protein electrophoresis and and a trace amount of IgA kappa paraprotein. This is the typical pattern of a Bence Jones protein.

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