Note: PDF files are for use by students for personal copies only

Tuesday, March 2, 1-3 pm

Exam 1 – Answer 5 of 6 questions based on the classes up to this point. Each question is worth 20 points.

Toxins, ctd.

13, 14. Thursday, Mar 4 1-3 pm

Salles II, Tucker AE, Voth DE, Ballard JD. Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12426-31. (Wilson presenting) PDF (461 KB)

Kirby JE. Anthrax lethal toxin induces human endothelial cell apoptosis. Infect Immun. 2004 Jan;72(1):430-9. (Barbu presenting) PDF (6663 KB) LARGE!!

15. Tuesday, Mar 16

Kubori T, Galan JE. Temporal regulation of Salmonella virulence effector function by proteasome-dependent protein degradation. Cell. 2003 Oct 31;115(3):333-42. (Estrella presenting) PDF (54 kb)

16. Thursday, Mar 18

Ilver D, Barone S, Mercati D, Lupetti P, Telford JL Helicobacter pylori toxin VacA is transferred to host cells via a novel contact-dependent mechanism. Cell Microbiol. 2004 Feb;6(2):167-74. (Koehler presenting) PDF (361 KB)

Secretion and Pathogenesis

Peter J. Christie, Ph.D.

MSB 1. , 713-500-5440

Peter.J.Christie@uth.tmc.edu

17. Tuesday, March 23, 2004. Secretion and Pathogenesis I (Christie)

Assigned Article:

Hinsa, S.M et al. 2003. Transition from reversible to irreversible attachment during biofilm formation by Pseudomonas fluorescens WCS365 requires an ABC transporter and a large secreted protein. Mol. Microbiol. 49:905-918. PDF (419 KB)

Useful Review:

Thanassi, D.G. and S. J. Hultgren. 2000. Multiple pathways allow protein secretion across the bacterial outer membrane. Curr. Op. Cell Biol. 12:420-430. PDF (2012 KB)

18. Thursday, March 25, 2004. Secretion and Pathogenesis II (Meaux)

Assigned Article:

Kirn, T. et al. 2003. Secretion of a soluble colonization factor by the TCP type 4 pilus biogenesis pathway in Vibrio cholera. Mol. Microbiol. 49:81-92. PDF (350 KB)

Useful Review:

Peabody, C. R. et al. 2003. Type II protein secretion and its relationship to bacterial type IV pili and archeal flagella. Microbiology 149:3051-3072. PDF (382 KB)

19. Tuesday, March 30, 2004. Secretion and Pathogenesis III (Wilson)

Assigned Article:

Lee, S. H. and J. E. Galan. 2004. Salmonella type III secretion-associated chaperones confer secretion-pathway specificity. Mol. Microbiol. 51:483-495. PDF (469 KB)

Useful Review:

Thomas, N. and B. Finlay. 2003. Establishing order for type III secretion substrates – a hierarchical process. Trends Microbiol. 11:398-403. PDF (LARGE! 6532 KB)