Molecular Basis of Microbial Pathogenesis - 2011

MicPath Articles - March

Note: It may be necessary to log in to the HAM-TMC Library website to acquire some of the articles.

 

Secretion and Pathogenesis

(Dr. Christie)

Tuesday, March 1.     Youmans    

Assigned article

Abdallah AM, Verboom T, Weerdenburg EM, Gey van Pittius NC, Mahasha PW, Jiménez C, Parra M, Cadieux N, Brennan MJ, Appelmelk BJ, Bitter W.  PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5. Mol Microbiol. 2009 Aug;73(3):329-40. Epub 2009 Jul 7.  Link  Supplement

Useful review

Bottai D, Brosch R.  Mol Microbiol. Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families.  2009 Aug;73(3):325-8. Epub 2009 Jul 7.  Link.

 

Fungal Pathogenesis

(Dr. Lorenz)

Thursday, March 3.      (Nobles)

Assigned Article:

Nobile, et al. (2008) Complementary adhesin function in C. albicans biofilm formation.  Curr. Biol. 18:1017.  Link

Introductory review 

Finkel and Mitchell (2011)  Genetic control of Candida albicans biofilm development.  Nat. Rev. Microbiol. 9:109.  Link  (You may need to login to the library to access this article)

 

Tuesday, March 15.       (Bakhru)

Assigned Article: 

Almeida, et al. (2008) The hyphal-associated adhesin and invasin ALS3 of Candida albicans mediates iron acquisition from host ferritin.  PLoS Pathog. 4:e1000217. Link

Introductory review 

Liu and Filler (2011) Candida albicans ALS3, a multifunctional adhesin and invasin.  Eukaryot. Cell 10:168.  Link

Thursday, March 17.     (Tiller)

Assigned Article:

Frohner, et al. (2009)  Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance.  Mol. Microbiol. 71:240.  Link

Introductory review 

Dr. Lorenz will send the students a pdf of a book chapter that will provide an intro to the last two papers.

 

Tuesday, March 22.   (Youmans)

Assigned Article:

Luo, et al. (2009)  Immune evasion of the human pathogenic yeast Candida albicans:  Pra1 is a Factor H, FHL-1, and plasminogen binding surface protein.  Mol. Immunol. 47:541.  Link

 

Thursday, March 24, 8:30-4:00. 

Molecular Basis of Infectious Diseases Retreat   - Please Attend

Institute of Molecular Medicine

 

Surface structures and virulence

(Dr. Ton-That)

Tuesday, March 29.  (Nobles)

Assigned Article:

Boettcher JP et al. Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.  PLoS Biol. 2010 Aug 24;8(8).   Link

 

Thursday, March 31.  (Bakhru)

Assigned Article:

Cegelski L et al. Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.  Nat. Chem. Biol. 2009 Dec;5(12):913-9.  Link

 

If you have trouble with obtaining the .pdf file via the link, please contact Dr. Norris at Steven.J.Norris@uth.tmc.edu.)