Mathematical algorithm

A list of differential diagnoses is provided by the database with each set of input data. The differential diagnoses have an assigned value of profile factor (PF). The PF value for a neoplasm reflects how well its immunophenotyping pattern matches that of a given case. In this project, accumulated data from published literature are utilized to enhance the sensitivity and specificity of the differential diagnosis. The formula for calculating PF is as following:

Where

PF : profile factor for a particular neoplasm (0 ≤ PF ≤ 1)

Cn : profile coefficient for an input data (0 ≤ Cn ≤ 1)

n = 1 to N

N : the number of (not-NULL) attributes of a neoplasm that have input data

The profile coefficient is calculated as:

Cn = PosRatio(i,j) if input data is positive (+), and NegRatio(i,j) if input data is negative (-)

The ratio of cases that are positive for a certain marker for a disorder, PosRatio(i,j), is defined as:

Where

i: the i th disorder

j: the j th marker

: number of cases that are positive for the j th marker for the ith disorder

: number of cases under study for the j th marker for the ith disorder

The ratio of cases that are negative for a certain marker for a disorder, NegRatio(i,j), is calculated as:

= 1 -